11th March 2025

BNF for Children

This update contains 1 significant change and 2 new preparations.

Significant Changes:

• Pneumococcal polysaccharide conjugate vaccine (adsorbed): name change of Apexxnar® to Prevenar 20®.

New Preparations: Hyftor® [sirolimus]; Verorab® [rabies vaccine].

11th March 2025

British National Formulary

This update contains 3 significant changes, 3 new monographs and 3 new preparations.

Significant Changes:

• Andexanet alfa [therapeutic use changed to reversal of anticoagulation].
• Idarucizumab [therapeutic use changed to reversal of anticoagulation].
• Pneumococcal polysaccharide conjugate vaccine (adsorbed): name change of Apexxnar® to Prevenar 20®.

New Monographs:

• Balversa® [erdafitinib].
• Vafseo® [vadadustat].
• Wainzua® [eplontersen].

New Preparations: Cequa® [ciclosporin]; Hyftor® [sirolimus]; Verorab® [rabies vaccine].

11th March 2025

Martindale’s ADR Checker

This update contains 10 new drugs, 29 minor updates, 100 new or updated pieces of short management advice, and 7 existing drugs have been revalidated.

11th March 2025

AHFS Drug Information

This update contains 4 new monographs, 38 revised monographs and 23 discontinued Monographs.

New monographs: Crinecerfont; Landiolol Hydrochloride; Olezarsen Sodium; Remestemcel-L-rknd.

Revised monographs: Abacavir Sulfate; Benzgalantamine Gluconate; Cabotegravir and Rilpivirine; Cabotegravir, Cabotegravir Sodium; Crisaborole; Dapagliflozin Propanediol; Darbepoetin Alfa; Deutetrabenazine; Dolutegravir Sodium and Lamivudine; Doravirine; Doravirine, Lamivudine, and Tenofovir Disoproxil Fumarate; DULoxetine Hydrochloride; Duvelisib; Eculizumab; Emtricitabine; Etravirine; Fezolinetant; Fosamprenavir Calcium; Guselkumab; Iloprost (Frostbite); Lazertinib Mesylate; Lonapegsomatropin-tcgd; Lotilaner; Macitentan and Tadalafil; Mavacamten; Metoclopramide Hydrochloride; Nelfinavir Mesylate; Nirmatrelvir and Ritonavir; Ravulizumab-cwvz; Respiratory Syncytial Virus Vaccine; Respiratory Syncytial Virus Vaccine, Adjuvanted; Ribociclib Succinate; Selpercatinib; Sparsentan; Tipranavir; Velmanase Alfa-tycv; Voclosporin; Zuranolone.

Discontinued monographs: Aducanumab; Antiretroviral General Statement; Bamlanivimab and etesevimab; Bebtelovimab; Belladonna; Casirivimab and imdevimab; Cefotaxime; Ceftobiprole; Copanlisib; HMG-CoA Reductase Inhibitors General Statement; Infigratinib; Insulin detemir; Olaratumab; Omacetaxine; Oprelvekin; Peginterferon alfa-2b; Rosiglitazone; Sodium phenylbutyrate and taurursodiol; Sotrovimab; Tixagevimab and cilgavimab; Vitamins A and D; Vorapaxar; Voxelotor.

11th March 2025

Stockley’s Interactions Checker

For March, 290 new interactions have been added, and 73 existing interactions have been updated.

11th March 2025

Martindale: The Complete Drug Reference

This update contains 4 new monographs and 29 existing monographs have been updated. Preparations have also been updated for 4 countries.

New Monographs

• Olutasidenib is an inhibitor of isocitrate dehydrogenase-1 (IDH1) that is used for the treatment of relapsed or refractory acute myeloid leukaemia with an IDH1 mutation.
• Omaveloxolone is an activator of the nuclear factor (erythroid-derived 2)-like 2 (Nrf2) pathway, which is involved in the cellular response to oxidative stress. It is used for the treatment of Friedreich’s ataxia.
• Pirtobrutinib is an inhibitor of Bruton’s tyrosine kinase that is used in the treatment of relapsed or refractory mantle cell lymphoma, and relapsed or refractory chronic lymphocytic leukaemia or small lymphocytic lymphoma.
• Zilucoplan is a synthetic macrocyclic peptide that acts as a complement blocker by inhibiting complement activation at both the C5 protein and the C5b protein moiety. It is used in the treatment of generalised myasthenia gravis.

Selective Updates – some new, re-validated or changed information

Monographs

• Artichoke (formerly Cynara)
• Asafoetida (formerly Asafetida)
• Bilberry (formerly Myrtillus)
• Black Cohosh (formerly Cimicifuga)
• Bloodroot (formerly Sanguinaria)
• Blue Flag (formerly Iris Versicolor)
• Bogbean (formerly Menyanthes)
• Burdock (formerly Lappa)
• Couch Grass (formerly Couch-grass)
• Cramp Bark (formerly Viburnum Opulus)
• Eyebright (formerly Euphrasia)
• False Unicorn (formerly Helonias)
• Goat’s Rue (formerly Galega Officinalis)
• Goldenseal (formerly Hydrastis)
• Holy Thistle (formerly Cnicus Benedictus)
• Hops (formerly Lupulus)
• Horse-chestnut (formerly Aesculus)
• Horsetail (formerly Equisetum)
• Lady’s Slipper (formerly Cypripedium Pubescens)
• Lime Flower (formerly Tilia)
• Marshmallow (formerly Althaea)
• Methylsulfonylmethane (formerly Dimethyl Sulfone)
• Passionflower (formerly Passion Flower)
• Pumpkin Seed (formerly Cucurbita)
• Rilpivirine
• Tivozanib
• Tribulus (formerly Tribulus Terrestris)
• White Horehound (formerly Marrubium)
• Yarrow (formerly Achillea)

Updated names, synonyms and codes; official standards; official preparations

• ATC and ATC (veterinary) codes 2025
• BP 2024
• Eur. 11.3
• WADA 2025 processing

Proprietary Preparations and Manufacturers updated for the following countries and regions:

• Hong Kong
• Venezuela
• UK^†
• USA^†

† Countries updated on an ongoing basis