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Pharmaceutical Toxicology

Pharmaceutical Toxicology

Edited by Gerard J Mulder and Lennart Dencker

  

  

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Explains the methodology and requirements of pre-clinical safety assessments of new medicines.

ISBN9780853695936
Published1st Jun, 2006
Dimensions234 x 156 mm
Page count280

Description

Toxicology studies are carried out on all drug substances to ensure safety. With the focus on medicinal drugs, the most important safety issues of drugs are covered. This includes registration requirements of new drugs and pharmacovigilance.

The book includes a general introduction and chapters on basic toxicological principles, organ toxicity of drugs is illustrated by chapters on toxicity in the liver, in the kidney, in the respiratory system and in the immune system.

This book combines a broad treatment of the issues relevant for assessing the safety/efficacy balance of a new drug with information on the toxicological knowledge base and methodology.

This is an introductory text for students at BSc, MSc and PhD levels, and will be an excellent companion to pharmacology textbooks.

• General Toxicology
• Drug Metabolism: Inactivation and Bioactivation of Xenobioptics
• Molecular and Cellular Mechanisms of Toxicity
• Teratology
• Genotoxicity
• Carcinogenicity of Drugs
• Liver Toxicity
• Kidney Toxicity
• Toxicology in the Respiratory System
• Immunotoxicity
• Clinical Toxicology
• Safety Assessment of Pharmaceuticals: Regulatory Aspects
• Pharmacovigilance

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